BACK

Preventing Overdose
By Andrew Preston, Paul Hardacre, Jon Derricott and Neil Hunt.

Introduction
Causes of overdose
Risk factors
Injecting and mixing drugs
Deliberate overdose
Drug treatment and overdose
Responding to overdose

First aid training
Calling an ambulance
Myths
10 key strategies for reducing overdose deaths
Useful contacts
Bibliography and further reading
Credits

Introduction
In the future, cigarette smoking and viral infections such as hepatitis C and HIV will cause the death of large numbers of people who inject illicit drugs. However, at the time of writing, overdose is the largest cause of death amongst injectors.

The numbers of illicit drug users dying as a result of overdose rose steadily during the 1990s - from approximately 250 in 1991, to 600 in 1997, and higher towards the end of the decade.

People who inject heroin are about 14 times more likely to die than their peers. The average age of people dying through heroin related overdose is just 30 years. While heroin related overdose deaths are

relatively small in number in comparison to the number of deaths arising from alcohol or tobacco use, the potential life years lost per overdose death is greater than that associated with death resulting from alcohol or tobacco use. In Australia it has been estimated (using 1992 data) that overdose deaths represent over 20,000 years of life lost.

The Commonwealth Department of Health and Aged Care ‘National Heroin Overdose Strategy’ reported that there were 958 deaths attributable to opioid overdose among those aged 15 - 44 years in 1999. Many of these deaths could have been prevented.

Up to 60% of injecting heroin users report having experienced at least one overdose, while up to 70% have witnessed someone else overdosing.

Research shows that around 60% of overdose deaths occur in the presence of others, and that sudden death immediately after injecting is rare, occurring in only 15% of cases.

This suggests that if drug services provide appropriate information, training and support on how to respond to an overdose, it is likely that the number of overdose deaths can be reduced.

We have designed this guide, and the campaign materials that accompany it, to help services working with injecting drug users to work in a concerted way to:

1. Get the key messages across to injecting drug users that:

  • injecting drugs;
  • mixing drugs and alcohol;
  • mixing opiates and other drugs; and
  • using opiates when tolerance is low, particularly after prison, detoxification or a break in use

all increase the risk of overdose.

2. Encourage people who might witness an overdose to give appropriate first aid and call an ambulance.
These simple actions are life-saving responses.

3. Consider implementing first aid training for:

  • staff;
  • injecting drug users; and
  • relatives of injecting drug users and others who may be likely to witness an overdose.

TOP

Causes of overdose
Only a minority of deaths that are reported as ‘heroin overdose’ or ‘methadone overdose’ are actually caused by taking just one drug.

More often, death is caused by using opiates in combination with other central nervous system depressants - especially alcohol, and benzodiazepines.

In the presence of other depressant drugs, a ‘normal’ or usual dose of heroin may prove fatal.
Indeed the blood levels of heroin in those who die has often been found to be:

  • less than that which would kill someone not used to taking heroin; and
     
  • no different to those of other people with a similar level of tolerance, who use the same amounts and survive.

In many cases of overdose, death occurs several hours after the drug (usually heroin) is injected.
This highlights some key issues in preventing death from overdose:

  • people present at an overdose oftenhave time to save life by putting the person in the recovery position and calling an ambulance; and
     
  • combinations of sedatives (especially when they include heroin and alcohol) are particularly dangerous.

TOP

Risk factors
There are a number of risk factors and behaviours that, if identified, can predict those drug users who are at greater risk of dying from an overdose. Awareness of these amongst both those working with injecting drug users, and injecting drug users themselves, may help to reduce the number of deaths caused by overdose.

These risks can be summarised as:

  • injecting heroin;
  • history of previous non-fatal overdose;
  • longer history of injecting;
  • high levels of drug use or intoxication;
  • high levels of alcohol use;
  • low tolerance;
  • depression, feelings of hopelessness and suicidal thoughts;
  • a history of using combinations of drugs including benzodiazepines or alcohol;
  • higher risk injecting behaviours, such as sharing or using used equipment; and
  • not being in a methadone or other treatment programme.

TOP

Injecting and mixing drugs
Non-fatal overdose is common among injecting heroin users. It has been estimated that between 12,000 and 21,000 non-fatal overdoses occur in Australia every year.

Just as talking to injectors about their experience of witnessing overdose can create opportunities to improve the first aid and other responses, so talking to injectors about their past history of non-fatal overdose may help to identify, and reduce, risk factors.

Using combinations of depressant drugs is a major cause of overdose. As well as the possibility of potentiating (increasing the effectiveness of) each other, it is likely that drug users often do not fully appreciate the risks of:

  • mixing heroin (especially when injected) with other sedative drugs taken some hours earlier;
  • mixing heroin and other sedatives with methadone, which is a very long-acting opiate; and
  • using combinations of drugs and alcohol.

A history of recent heavy drinking is one of the most consistent predictors of how likely a heroin user is to overdose. This is an issue that all drug services need to tackle, in terms of assessment and advice and information giving.

Contrary to popular belief, variations in drug purity only account for a small proportion of overdose deaths.

TOP

Deliberate overdose
While impossible to quantify, it is thought that deliberate overdose - with some degree of prior suicidal thought or intent - may account for up to a third of overdose deaths.

Suicidal thoughts can be an important factor in overdose, and workers should make sure that clients have the opportunity to explore this area. Talking about these problems is likely to reduce the risk.

People who are in methadone treatment appear to be more likely to attempt suicide than people who are opiate dependent and are not in treatment. This may be because they have more severe problems. However, as they should also have access to counselling and support, this is an area of risk that it should be possible to reduce.

For those heroin injectors who feel that life has little to offer, there may be a grey area between suicidal intent and neglecting personal safety. A feeling that life is not worth protecting can hamper efforts to get injectors to act on life-saving messages. Services which improve the quality of life for their clients are probably indirectly helping to reduce the risk of overdose.

Cocaine and speed overdose can cause strokes and heart problems. They can also play a role in deaths due to sedative overdose drug use by temporarily masking sedative effects and contributing to a feeling that reckless behaviour will be safe.

TOP

Drug treatment and overdose
Although methadone is dangerous in overdose (particularly for people who are not tolerant to its effects), scientific evidence shows that
being in effective methadone maintenance treatment (that is treatment with adequate doses, high levels of supervision, support and retention) greatly reduces the risk due to overdose in heroin injectors.

Heroin injectors not in methadone treatment are around four times more likely to die than those who are in treatment. This is mainly because people in methadone treatment use much less heroin.

The start of treatment is associated with a higher risk of overdose than later in treatment. It may be possible to reduce the risk of death at the start of treatment by:

  • careful assessment;
     
  • ensuring that the initial dose, when commencing or re-commencing treatment, is low (usually less than 30mg); and
     
  • supervised consumption of initial doses.

Ending treatment prematurely is also associated with increased overdose risk. This may be due to a number of factors including loss of tolerance if the treatment has ended following detoxification, and increased poly drug use as the cause, or consequence, of treatment ending.

Treatment services can cut the number of deaths by being attractive to drug users and by retaining them in treatment. Conversely, services with high rates of discharge put patients at risk.

Detoxification programs have a strong relationship with overdose deaths. Resumption of opioid use following periods of reduced consumption or abstinence increases the risk of overdose.

It is important that services offering opportunities for people to become drug free, tackle the issue of helping clients to manage the overdose risk if they return to drug/alcohol use.

TOP

Responding to overdose
In the mid 1980s it became clear that drug injectors were prepared to change their behaviour in order to reduce HIV risk. Reassuringly, current injectors also seem open to messages about preventing overdose and first aid.

Despite research which indicates that approximately 60% of overdose deaths occur when others are present, and that sudden death immediately after injecting occurs in only 15% of cases, it has been shown that in 79% of cases there is no intervention by bystanders before death.

It may be that heroin injectors witnessing overdoses, having seen non-fatal overdoses before, are over-optimistic about the probable outcome.

There is also evidence that deep snoring, associated with breathing difficulties, is sometimes thought to be someone sleeping soundly.

Many drug users do not realise that there is often a long time delay (often several hours) between injecting heroin and overdose death. People who witness overdoses may wrongly assume that, following survival of the initial ‘hit’, the risk of death reduces.

All potential witnesses of an overdose including:

  • drug workers;
  • injecting drug users; and
  • their family and friends;

should be aware of the signs of overdose. The signs of unconsciousness they should be able to identify include:

  • deep snoring;
  • unwakeable;
  • turning blue; and
  • not breathing.

People who witness overdoses need to be able to identify the transition from sleep to unconsciousness so that they can give appropriate first aid.

If someone is unconscious and lying on their back, their airway can become blocked by their tongue, vomit or saliva in the back of the mouth. This can stop them breathing and result in death.

This type of death can be avoided if someone puts the unconscious person into the recovery position.

All staff in contact with injecting drug users should be able to teach this skill.

Injectors should be encouraged to practice the recovery position and to teach it to their peers.

The poster, booklet and intervention pad that accompany this campaign are available as teaching aids to help workers and drug users to pass on this skill among people who take heroin.

Learning how to put someone in the recovery position is something that is best learnt in practice. Where appropriate, workers should teach this skill by example.

This brief intervention can make a big difference to overdose fatalities.

Through concerted overdose awareness campaigns, drugs services should aim to achieve 100% awareness of how to put someone in the recovery position amongst injectors in contact with the service.

Drug services should also encourage wider knowledge of this important first aid message.

Expired Air Resuscitation (EAR) and Cardio-Pulmonary Resuscitation (CPR)
When people have stopped breathing, expired air resuscitation (also knownas ‘mouth-to-mouth’ resuscitation) is a simple technique which can save lives.

Training in expired air resuscitation (EAR) and cardio-pulmonary resuscitation (CPR) should be done in a workshop situation with a qualified trainer.

TOP

First aid training
First aid training covering:

  • risks and signs of overdose;
  • the recovery position;
  • expired air resuscitation (EAR); and
  • cardio-pulmonary resuscitation (CPR)

is essential for both injecting drug users and staff who work with them.

Many drug users who have witnessed overdoses would have been willing to resuscitate the victim, but couldn’t because they did not know how.

Staff need quality training in first aid, both to teach the skills to drug users and also to deal with overdose situations in the workplace.

Training can often be provided by the local ambulance service. This can have the added benefits of fostering understanding and trust between injecting drug users and ambulance staff.

If this is not possible or practical, St. John Ambulance and the Australian Red Cross have a national network of qualified first aid trainers who may be able to tailor courses to the needs of your staff and client group.

Consideration should be given to paying service users to come to first aid courses, as this can be a cost-effective way of saving lives.

TOP

Calling an ambulance
Dialling triple zero (000) and calling an ambulance should be an instant response. Don’t panic. Ensure that the person who has overdosed has beenplaced in the recovery position. Stay with the person until the ambulance arrives.

The ambulance service has the ability to respond to an overdose with a range of medical interventions. In the majority of overdoses, the short-acting opiate antagonist ‘naloxone’ (or ‘Narcan’) may not be required - keeping the person breathing will be the paramedic’s first priority.

According to a study by the Australian Institute of Criminology, using data from the 1998 National Drug Strategy Household Survey, 22% of witnesses of heroin overdose did not call for medical assistance because “they didn’t want to get involved,” and another 39% thought they were “capable of handling the overdose.” This reluctance to call an ambulance is costing lives.

As discussed, it may be that some people witnessing overdoses, having seen non-fatal overdoses before, are over-optimistic about what will happen.

Other reasons for not calling an ambulance include:

  • ambulance costs; and
  • previous negative experiences with hospital staff.

However, for many drug users the main reason ambulances are not called is fear that the police will attend and possibly:

  • arrest witnesses;
  • search the premises;
  • execute outstanding arrest warrants; and
  • pass information to the drug squad.

Collaboration between NSPs, drug services, police, and ambulance should result in a policy whereby the police are only called to those incidents where there has been a death, or where there is risk to the ambulance crew, children, or others.

Every NSP and drug service should work with the police and ambulance service to establish good practice.

Injecting drug users should be informed about the local policy, and encouraged to make sure that everyone who overdoses receives appropriate medical help.

TOP

Myths
As well as promoting appropriate responses to overdose, it is important to counter common myths and dangerous practices about how to respond to overdose situations.

The most usual of these centre around the idea that someone who is overdosing can be stimulated into regaining consciousness.

Practices to do this include:

  • putting people in a cold shower or bath;
  • walking (or dragging) them around the room; and
  • inflicting pain through hitting or even burning.

While it is important to assess the level of consciousness of someone who may have overdosed, if they cannot be roused when shaken and shouted at, they are unconscious - further stimulation will not change this.

Just as it is impossible to resist the effect of an anaesthetic through willpower, so it is impossible to overcome the effects of overdose by willpower or stimulation.

Putting people in a cold shower or bath is a particularly dangerous practice because:

  • it may take some time to run a bath - and the person may die during this delay;
  • there is a risk of drowning in a bath if placed in while unconscious; and
  • there may be a risk of hypothermia.

Trying to walk people around may also make the situation worse because the increased heartbeat may increase absorption of drugs from the intestine, and the helpers may drop the person having the overdose.

There is some understanding of this amongst drug users - in one study 92% of people who had witnessed overdose had tried stimulation, yet only 62% maintained that this was the right thing to do.

It is likely that with better information and first aid training, the desire to help can be turned from an intervention that may increase risk, into life-saving action.

Another dangerous practice which has been reported is that of injecting someone who has overdosed with salt water. There is no medical basis for this practice.

One explanation for it may be that drug users have seen people in hospital having a ‘drip’ put up. This is done to make sure medical staff are able to give intravenous medication. The fluid in the ‘drip’ is usually ‘normal saline’. This has tiny quantities of salt added to prevent disrupting the chemistry and fluid balance of the blood - it does not affect the overdose at all.

Injecting people with salt water is dangerous because it:

  • wastes time that should be spent putting the person in the recovery position and calling an ambulance; and
     
  • may result in exposure to viral infection if, in the haste and panic, the salt water is given in a used syringe.

TOP

10 key strategies for reducing overdose deaths
 

  1. Staff at NSPs and drug treatment agencies should have first aid training so that they can pass these skills on to injecting drug users and respond to overdose situations within the workplace.
     
  2. All injecting drug users in contact with services should be given written and spoken information on overdose risk factors and how to avoid them.
     
  3. First aid training should be made available to all injecting drug users, their relatives and friends who are likely to witness an overdose.
     
  4. First aid training must be delivered by qualified and competent staff (although they might usefully be helped by a drug worker or peer educator).
     
  5. Every prisoner with a history of opiate use and every opiate user leaving residential or other detoxification facility must be given information (such as the materials which accompany this guide) on the risks of overdose following a break in use and loss of tolerance.
     
  6. High-quality, accessible methadone treatment that keeps patients in treatment, reduces injecting, prioritises overdose risk and improves quality of life, should be available in all areas.
     
  7. Every accident and emergency department should give written and spoken information to every opiate user they see, about preventing and managing overdose.
     
  8. Police should not be called to the scene of an overdose unless it is essential.
     
  9. NSPs and drug treatment agencies should communicate local policies regarding the involvement of the police in overdose emergency calls to drug users.
     
  10. All ambulance crews should carry the opiate antagonist naloxone and be trained in how to use it.

TOP

Useful contacts
Queensland Ambulance Service
G P O Box 625
Brisbane QLD 4001
1300 650 377

St John Ambulance
St John House
225 St Pauls Tce
P O Box 1645
Fortitude Valley QLD 4006
1300 360 455
Email
info@stjohnqld.asn.au
www.stjohnqld.asn.au

Australian Red Cross
397 Adelaide Street
G P O Box 917
Brisbane QLD 4001
1300 367 428
Email
registration@qld.redcross.org.au
www.qld.redcross.org.au

TOP

Bibliography and further reading
Best D, Man L, Zador D, et. al. (2000) . Appreciating the extent and understanding the causes of opiate overdose: A thematic review. Findings, 1 (4), 1-4.

The Advisory Council on the Misuse of Drugs. (2000). Reducing drug related deaths. The Stationary Office. London.

Bennett G A, Higgins S. (1999) Accidental overdose among injecting drug users in Dorset UK. Addiction 94(8), 1179-1190

Caplehorn J R, Dalton M S, Haldar F et al. (1996) Methadone maintenance and addicts’ risk of fatal heroin overdose. Substance Use & Misuse, 31(2), 177-196.

Commonwealth Department of Health and Aged Care. (2001). National Heroin Overdose Strategy. Canberra: Commonwealth of Australia.

Darke S and Ross J, et al. (1996). ‘Overdose among heroin users in Sydney, Australia: I Prevalence and correlates of non-fatal overdose’ Addiction 91: 405-411.

Darke S and Ross J, et al. (1996). ‘Overdose among heroin users in Sydney, Australia: II Responses to overdose’ Addiction 91: 413-417.

Darke S and Zador D. (1996). ‘Fatal heroin ‘overdose’: a review’ Addiction 91: 1765-1772.

Darke S, Zador D (1996). ‘Fatal heroin ‘overdose’: a review’ Addiction 91 (12), 1765-1772.

Neale J, (2000). Suicidal Intent in non-fatal illicit drug overdose. Addiction. 95 (1), 85-93.

Strang J, Best D, Man L et al. (2000). Peer-initiated overdose resuscitation: fellow drug users could be mobilised to implement resuscitation. International Journal of Drug Policy, 437-445.

Strang J, Griffiths P, Powis B et al. (1999). Which drugs cause overdose among opiate misusers? Study of personal and witnessed overdoses. Drug and Alcohol Review 18, 253-261.

Warner-Smith M, Lynskey M, Darke S, Hall W. (2000). ‘Heroin overdose: prevalence, correlates, consequences and interventions Monograph No. 46’ National Drug and Alcohol Research Centre, University of New South Wales.

Zador D, Sunjic S, Darke S. (1996). ‘Heroin-related deaths in New South Wales, 1992: toxicological findings and circumstances’ Medical Journal of Australia 164: 204-207.

TOP

Credits
The ‘Preventing Overdose’ campaign has been edited for Australian conditionsby Paul Hardacre (Queensland Needle & Syringe Program) with the assistance of Lynne Biggs (Alcohol, Tobacco & Other Drug Services, Queensland Health), Ron Henderson and Peter Parmenter (Queensland Ambulance Service).

First aid information approved by Queensland Ambulance Service.

Published by Exchange Campaigns for Queensland Health.
© Exchange Campaigns 2003
info@saferinjecting.org

TOP | BACK